It is believed that 25% of cases of ED in some way connected with the intake of medicines. For example, the Massachusetts study on issues of aging men found that the frequency of ED was 28% among patients receiving treatment for diabetes, 39% among cardiac patients, and 15% among men - hypertensives receiving drug therapy. At present we know a large number of drugs that adversely affect the various links in a sexual act. Some of them have an effect on the central mechanisms of erection (antidepressants, antihypertensive medications central action), while others interact with the peripheral components of the arc at the level of the corpora cavernosa (blockers). Clinical signs of drug ED is relatively rapid onset, temporal association with drug intake, negatively affects the various links in a sexual act, and a decrease in severity of illness or its complete disappearance after discontinuation of the drug.
A special place in the pathogenesis of erectile dysfunction occupy such diseases as hypertension and diabetes. The main factor for the development of ED in this case becomes microangiopathy, which leads to a breach of circulation in cavernous bodies. The influx of arterial blood to the penis is carried out on the dorsal and cavernous arteries, originating from the internal pudendal artery. Further relaxation of smooth muscle elements of the cavernous tissue leads to filling of arterial blood lacunae. This, in turn, leads to compression of subtunikalnyh and emissarnyh venules and blocking the outflow of blood from the penis. This phenomenon is known as venookklyuzivny mechanism. Hypoxia, hypercholesterolemia, hyperglycemia leads to phenotypic changes in cavernous tissue - namely, to increase the synthesis and accumulation of collagen with the outcome in the cavernous fibrosis. Cavernous fibrosis is the main link in the pathogenesis of ED. At 48 h after the erection of the cavernous tissue develops, the degree of hypoxia, at which the induction of collagen synthesis in the cavernous tissue. Oxygenation cavernous tissue occurs during erection of the penis. In men with normal sexual function, not even sexually active, 4-8 episodes of spontaneous erections during the night to ensure adequate oxygenation cavernous tissue to prevent the changes leading to fibrosis. In diabetes the existing microcirculatory disorders aggravated by progressive autonomic neuropathy. There is a correlation between ED and coronary artery atherosclerosis. These diseases have common risk factors - hypertension, dyslipidemia, diabetes, smoking, sedentary lifestyle.
A special place in the pathogenesis of erectile dysfunction occupy such diseases as hypertension and diabetes. The main factor for the development of ED in this case becomes microangiopathy, which leads to a breach of circulation in cavernous bodies. The influx of arterial blood to the penis is carried out on the dorsal and cavernous arteries, originating from the internal pudendal artery. Further relaxation of smooth muscle elements of the cavernous tissue leads to filling of arterial blood lacunae. This, in turn, leads to compression of subtunikalnyh and emissarnyh venules and blocking the outflow of blood from the penis. This phenomenon is known as venookklyuzivny mechanism. Hypoxia, hypercholesterolemia, hyperglycemia leads to phenotypic changes in cavernous tissue - namely, to increase the synthesis and accumulation of collagen with the outcome in the cavernous fibrosis. Cavernous fibrosis is the main link in the pathogenesis of ED. At 48 h after the erection of the cavernous tissue develops, the degree of hypoxia, at which the induction of collagen synthesis in the cavernous tissue. Oxygenation cavernous tissue occurs during erection of the penis. In men with normal sexual function, not even sexually active, 4-8 episodes of spontaneous erections during the night to ensure adequate oxygenation cavernous tissue to prevent the changes leading to fibrosis. In diabetes the existing microcirculatory disorders aggravated by progressive autonomic neuropathy. There is a correlation between ED and coronary artery atherosclerosis. These diseases have common risk factors - hypertension, dyslipidemia, diabetes, smoking, sedentary lifestyle.
